Volume VI Issue II

Publication for  Volume 6 Issue 2, February 2019 is in process…

Formulation and Evaluation of Paliperidone Palmitate Loaded Nanoparticles Using Biodegradable Polymers

Sreekanth M.C, Reshmi K, K.G Parthiban, Jerome K George, Anusha Ajayakumar – February 2019 Page No.: 01-06

Paliperidone palmitate also known as 9-hydroxyrisperidone, is a dopamine antagonist and 5-HT2A antagonist of the typical antipsychotic class of medications. The present study intends to carry out the formulation and evaluation of Paliperidone palmitate loaded biodegradable nanoparticles. The major goals in designing nanoparticles as a delivery system are to control particle size, surface properties, and release of pharmacologically active agents so as to achieve the site specific action of the drug at the rational rate and dose. Nanoparticles are synthesized by the nano-precipitation method. Nanoparticles of paliperidone palmitate were obtained with high encapsulation efficiency 60-80%. Nanoparticles are generally characterized by their size, morphology, surface charge using the advanced microscopic techniques such as Scanning electron microscopy (SEM). Drug entrapment efficiency was determined by centrifugation. These studies suggest the feasibility of formulating paliperidone palmitate loaded nanoparticles using a biodegradable polymer (Gelatin) for the treatment of psychotic disorders.

Page(s): 01-06                                                                                                                   Date of Publication: 11 February 2019

 Sreekanth M.C
Assistant Professor, Department of Pharmaceautics, Nehru College of Pharmacy, Pampady, Thrissur-680588, Kerala, India

 Reshmi K
Nehru College of Pharmacy, Pampady, Thrissur-680588, India

 K.G Parthiban
Professor and HOD, Department of Pharmaceutics, Nehru College of Pharmacy, Pampady, Thrissur-680588, India

 Jerome K George
Assistant Professor, Department of Pharmaceutics, St. Johns College of Pharmaceutical Sciences and Research, Kattappana, Idukki-685508, India

 Anusha Ajayakumar
Assistant Professor, Department of Pharmaceutical Analysis, Nehru College of Pharmacy, Pampady, Thrissur-680588, India

[1]. Namita Rajput, Methods of Preparation Of Nanoparticles – A Review,International Journal Of Advances In Engineering & Technology, Jan., 2015. ©Ijaet, Vol. 7, Issue 4, Pp. 1806-1811
[2]. Biman Bhuyan*, Prakash Rajak, .Nanocrystal Technology And Drug Delivery. World journal of pharmaceutical research ,vol 3 issue 2,2940-2971
[3]. Janardhana RaoVascuri, Mukkanti Kagga,Badrinadh Gupta P., Vekariya N.A.* and Aminul Islama. Synthesis and characterization of related substances of Paliperidone, an antipsychotic agent, Scholars Research Library Der Pharmacia Lettre, 2011, 3 (6):240-249
[4]. Rakshitkaubhai Trivedi,RavikumarJupudi,Mukesh C Patel, Dipika R Trivedi. A Validated Spectrophotometric Method for Determination of Paliperidone Palmitate in Bulk Drug and its pharmaceutical dosage forms, Journal of pharmacy and pharmaceutical sciences Issn:2320-1215
[5]. Abdul Hasan Sathali. A*., Gopinath. M. Formulation and evaluation of PaliperidoneNanocrystals.J of Biomed Rx.2013,422-438
[6]. Poovi. G., Dhanalakshmi. U.M., Narayanan. N., Neelakanta Reddy., Preparation and characterization of Repaglinide loaded Chitoson polymeric nanoparticles, Res. J. Nanosci. Nanotechnol, 1(1), 2011, 12-24.
[7]. Kreuter J., Nanoparticles-based drug delivery systems, J Control Release, 1991, 16, 169-176
[8]. Kristl. J., Baumgartner. S., Kocbek. P., Preparation and evaluation of nanosuspensions for enhancing the dissolution of poorly soluble drugs, Int. J. Pharm, 312, 2006, 179-186.
[9]. Megha Agarwal, D P Nagar*, Nalini Srivastava and MK Agarwal. Chitosan Nanoparticles based Drug Delivery: an Update,IJAMR,2015,1-15
[10]. P. Sasikumar and P.M. Ayyasamy. Design and Characterization of Poly-Hydroxy Butyric Acid (PHB) Based Polymeric Nanoparticles for Controlled Release of Doxorubicin for Cancer Treatment,Int.J.Curr.Microbiol.App.Sci(2015) 4(12): 311-317
[11]. AmolkumarLokhande, Satyendra Mishra, RavindraKulkarni, JitendraNaik., Formulation And Evaluation Of Glipizide Loaded Nanoparticles,International Journal Of Pharmacy And Pharmaceutical Sciences,Vol5,2013
[12]. Satya T, SivasankaraYadav G K, Chakravarthy I E. A new simple UV spectrophotometric determination of Paliperidonepalmitate in tabletsInternational journal of engineering sciences and research technology,2014,411-413
[13]. Kumar Ganesh,DhayaniArchana,KoyalPreeti. Review article on targeted polymeric nanoparticles. American journal of advanced drug delivery,2015,196-215
[14]. Jawahar. N., NagasamyVenkatesh. D., Sureshkumar. R.,Senthil. V., Ganesh. G.N.K., Vinoth. P., SumeetSood., Samanta.M.K., Development and charecterization of PLGAnanoparticles containing Carvedilol, J. Pharm. Sci. & Res,1(3), 2009, 123-128
[15]. Annick Ludwig., Kathleen Dillen., Jo Vandervoort., Guy VandenMooter., Evaluation of Ciprofloxacin-loaded Eudragit®RS100 or RL100/PLGA nanoparticles, Int. J. Pharm, 314, 2006,72-82.
[16]. BaharehAzimi, ParvizNourpanah, Mohammad Rabiee and ShahramArbab.Producing Gelatin Nanoparticles as Delivery System for Bovine Serum Albumin.,Iranian Bio medical Journal,2014,34-40

Sreekanth M.C, Reshmi K, K.G Parthiban, Jerome K George, Anusha Ajayakumar “Formulation and Evaluation of Paliperidone Palmitate Loaded Nanoparticles Using Biodegradable Polymers” International Journal of Research and Scientific Innovation (IJRSI) vol.6 issue 2, pp.01-06 February 2019  URL: https://www.rsisinternational.org/journals/ijrsi/digital-library/volume-6-issue-2/01-06.pdf

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Concept Generation of Soybean Threshing Machine
Harsha A, Mayur Appaiah – February 2019 – Page No.: 07-10

This paper is regarding the selection of effective mechanism for the Soybean threshing machine out of several other alternatives based on the Pugh Matrix and Concept scoring matrix method.

Page(s): 07-10                                                                                                                   Date of Publication: 11 February 2019

 Harsha A
Department of Industrial Engineering & Management, B.M.S. College of Engineering, VTU PG Extension Centre, Bangalore-560019, Karnataka, India

 Mayur Appaiah
Asst. Professor, Department of Industrial Engineering & Management, B.M.S. College of Engineering, VTU PG Extension Centre, Bangalore-560019, Karnataka, India

[1]. A.K.Goel, D.Behera, S. Swain and B.K.Behera Performance evaluation of a low-cost manual Sunflower thresher Indian J. Agric. Res., 43 (1) : 37-41, 2009
[2]. Archer, B. (1974). Design awareness and planned creativity in industry. Toronto: Thorn Press Limited. ISBN 0-85072-016-8.
[3]. Karl T. Ulrich and Steven D. Eppinger(2004).Product design and development : ISBN 007-247146-8
[4]. Somashekara, B.Ramesh Nayak and Raghu T, “Design and Development of Low Cost Shoe Polishing Machine”, IJSRD – International Journal for Scientific Research & Development, Vol. 4, Issue 06, 2016 | ISSN (online): 2321-0613
[5]. Mayur Appaiah, B. Ramesh Nayak, “Design of a Saw Blade for a Power Tool Attachment”, International Journal of Research and Innovations in Science and Technology, Vol. 1, Issue 01, 2014 | ISSN (online):2394-3858
[6]. Anil – Joshi; T. Guruswamy; S. R. Desai; J. T. Basavaraj and A. Joshi (1998). Effect of cylinder speed and feed rate on the performance of thresher. Collage of Agricultural Engineering Raichur – 584101, India Karnataka – Journal of Agricultural Sciences. 1998, 11 (4); 1120 – 1123.
[7]. Kausal, R. T., B. N. Patel; S. R. Kadam and N. R. Pavitrakar (2003). Case study on harvesting and threshing methods of sunflower Technology Research Unit, 4444, 104 (M.S), India. Annals of plant physiology; 2003, 17 (1): 34 – 38.
[8]. S. H. Yeo, M. W. Mak and A. P. Balon, “Analysis of Decision-Making Methodologies for Desirability Score of Conceptual Design,” Journal of Engineering Design, Vol. 15, No. 2, 2004, pp. 195-208.
[9]. J. Wang, “Improved Engineering Design Concept Selection Using Fuzzy Sets,” International Journal of Computer Integrated Manufacturing, Vol. 15, No. 1, 2002, pp. 18-27.

Harsha A, Mayur Appaiah “Concept Generation of Soybean Threshing Machine ” International Journal of Research and Scientific Innovation (IJRSI) vol.6 issue 2, pp.07-10 February 2019 URL: https://www.rsisinternational.org/journals/ijrsi/digital-library/volume-6-issue-2/07-10.pdf

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Man as Spiritual Being: Especially Tagore and Dr. Radhakrishnan’s View
Dr. Nirupama Bhattacharyya – February 2019 – Page No.: 11-12

The work gives an account of the views of Tagore and Radhakrishnan on man as spiritual being. The comparative and analytical study of views of both the philosophers will through new light of development in study of contemporary Indian philosophy. The capacity of man is finite. Man cannot with all its vigour and talent overcome the nature. It is dependent upon nature. The untamed umpteen endeavors of man pay a great dividend which elevated man above animal. Discussion would be carried out on Tagore’s concept of man as spiritual. Dr. Radhakrishnan regards man as essentially spiritual. The man is guided by certain ideals also shows that man is spiritual being. These ideals are Truth, Beauty, and Goodness.

Page(s): 11-12                                                                                                                   Date of Publication: 11 February 2019

 Dr. Nirupama Bhattacharyya
SIBSAGAR College, Sivasagar, Assam, India

[1]. Sinha,HP, 1993, Religious Philosophy Tgr and Rdhkrsnn, MotilalBndas, (1)-69
[2]. Tagore Rabindranath. 1949,The Religion of Man. London: George Allen and Unwin, P: 14
[3]. Ibid, 43
[4]. Radhakrishnan, Religion and Society, P:66
[5]. Radhakrishnan, Muirhead, The spirit of Man in contemporary Indian Philosophy, P:484
[6]. Tagore Rabindranath. Sadhana. London: Macmillan, 1954.
[7]. Mukherjee Jaya. Tagore and Radhakrishnan. Patna: Janaki, 1992.
[8]. Sinha Harendra Prasad. Religious Philosophy of Tagore and Radhakrishnan. Delhi: Motilal Banarsidass, 1993.
[9]. Salkar KR. Rabindranath Tagore: His Impact on Indian Education. New Delhi: Sterling, 1990

Dr. Nirupama Bhattacharyya “Man as Spiritual Being: Especially Tagore and Dr. Radhakrishnan’s View” International Journal of Research and Scientific Innovation (IJRSI) vol.6 issue 2, pp. 11-12 February 2019 URL: https://www.rsisinternational.org/journals/ijrsi/digital-library/volume-6-issue-2/11-12.pdf

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A Study on Behavior and Mechanical Properties of Polyester Based Composite Materials

Dr. Naveen Kumar G, Suresh Kumar C – February 2019 Page No.: 13-16

This review paper represents the study of different parameters, properties, behaviors and testing of Composite Materials. The studies of composite material can be done from different articles in the period of 2009 to 2019 and this paper reviewed from: Brief study on Mechanical Testing and their properties, fatigue behavior and its group properties like (Ultimate strength, Yield stress, and Elasticity Modulus) of prosthetic for partial foot amputation, Experimental analysis of unsaturated polyester reinforced by ceramic particles of alumina for implementation on human body, The process of occurring failure and solution to analysis the problem faced by drill twist of drilling operation on composite materials, The Design of Experiment is to evaluate effect of design parameter on dynamic response of laminated composite lattice cylinder shell, The Discussion of properties and geometric parameters on plastic zone size, The Investigation of fatigue Test can made on polymer composite material, The Technology in shielding can be discussed to improve better development in Fabrication process. In this paper the discussion reviews on basic study of composite materials.

Page(s): 13-16                                                                                                                   Date of Publication: 18 February 2019

 Dr. Naveen Kumar G
Mechanical Engineering Department, Institute of Aeronautical Engineering, Dundigal, Hyderabad-500043, India

 Suresh Kumar C
Mechanical Engineering Department, Institute of Aeronautical Engineering, Dundigal, Hyderabad-500043, India

[1]. N.Saba et. “An overview of mechanical and physical testing of composite materials” Mechanical and Physical Testing of Bio composite, fiber-Reinforced composites and Hybrid composites (2019).
[2]. SaifM.Abbas et. “Mechanical and fatigue behaviors of prosthetic for partial foot amputation with various composite materials type effect” International Journal of Mechanical Engineering and Technology, volume -9, Issue 9, September 2018, PPT 383-394.
[3]. C.C.Tsao et. “Effect of tool wear on delamination in drilling composite materials” International Journal of Mechanical Sciences, 49(2007) 983-988.
[4]. Luiz Fernando Dos Santos Souza et. “Dynamic response of laminated composites using design of experiments: An experiment and numerical study” Mechanical systems and Signal Processing, Elsevier,2018.
[5]. Zainad S. Al- Khafaji et. “Preparation and modeling of composite materials (Polyester- Alumina) as implant in human body”, International Journal of Mechanical Engineering and Technology, volume 9, Issue 4, April 2018, PP. 468-478.
[6]. Kai wei et. “Lightweight composite lattice cylindrical shells with novel character of Tailorable thermal expansion”, International Journal of Mechanical Sciences, 134(2018) 77-85.
[7]. M.Fan et. “Elastic-plastic stress investigation for an arc-shaped interface crack in composite material”, InternationalJournal of Mechanical Sciences, 83)2014) 104-111.
[8]. TarekMerzoukiet. “Direct identification of nonlinear damage behavior of composite materials using the constructive equation gap method”, International Journal of Mechanical Sciences, 89(2018) 487-499.
[9]. D.D. Doan et. “An unsupervised pattern recognition approach for AE data originating from fatigue test on polymer composite material”, Mechanical System and Signal Processing(2015).
[10]. BevenR.Evanset. “Evalution of shielding performance for newly developed composite materials”, Annals of Nuclear Energy 116(1018) 1-9

Dr. Naveen Kumar G, Suresh Kumar C “A Study on Behavior and Mechanical Properties of Polyester Based Composite Materials” International Journal of Research and Scientific Innovation (IJRSI) vol.6 issue 2, pp.13-16 February 2019  URL: https://www.rsisinternational.org/journals/ijrsi/digital-library/volume-6-issue-2/13-16.pdf

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A Study on Contributor Factors of Depression, Anxiety and Stress Scale (DASS) Questionnaire among Children in Shelter Care Institutions in Terengganu Malaysia

Siti Hajar, A. R., Farah Nasuha, S., Hanisah, I., Ahmad Bisyri, H. M. M., & Nuruaslizawati, A. – February 2019 Page No.: 17-21

This study aims to identify the most contributed factors in Depression, Anxiety and Stress Scale (DASS) questionnaire among children in Shelter Care Institutions in Terengganu Malaysia. The sample consists of 234 respondents from six institutions by using 21-items version of the DASS-21 questionnaire. Principal Component Analysis (PCA) was used to study the most essential contributed factor in the questionnaire. The initial PCA show five variables factors out of 21-item as the most significant for factors with a considerable eigen value > 1. The result from factor loading after varimax rotation show that VF1 has five variables, VF2 and VF3 has four variables, VF4 has two variables while VF5 has three variables. We suggest that the further study might be required to assess the status among gender and level of academic.

Page(s): 17-21                                                                                                                   Date of Publication: 18 February 2019

  Siti Hajar, A. R.
Faculty of Applied Social Sciences, Universiti Sultan Zainal Abidin, Kuala Nerus, Terengganu Malaysia

  Farah Nasuha, S.
Faculty of Applied Social Sciences, Universiti Sultan Zainal Abidin, Kuala Nerus, Terengganu Malaysia

  Hanisah, I.
Faculty of Applied Social Sciences, Universiti Sultan Zainal Abidin, Kuala Nerus, Terengganu Malaysia

  Ahmad Bisyri, H. M. M.
Faculty of Applied Social Sciences, Universiti Sultan Zainal Abidin, Kuala Nerus, Terengganu Malaysia

  Nuruaslizawati, A.
Faculty of Applied Social Sciences, Universiti Sultan Zainal Abidin, Kuala Nerus, Terengganu Malaysia

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Siti Hajar, A. R., Farah Nasuha, S., Hanisah, I., Ahmad Bisyri, H. M. M., & Nuruaslizawati, A. “A Study on Contributor Factors of Depression, Anxiety and Stress Scale (DASS) Questionnaire among Children in Shelter Care Institutions in Terengganu Malaysia” International Journal of Research and Scientific Innovation (IJRSI) vol.6 issue 2, pp.17-21 February 2019  URL: https://www.rsisinternational.org/journals/ijrsi/digital-library/volume-6-issue-2/17-21.pdf

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Nutritional Composition of Yam Flour Fortified with Soy-Pomace
Gbenga Daniel Abata, Emmanuel Orimisan Abata, Daniel Babatunde Lene, Margaret M. Mosimabale – February 2019 – Page No.: 22-24

In an attempt to improve the nutritional quality and quantity of yam flour [Elubo] a local dish from yam, soybean pomace was produced and added to the yam flour at different ratios. Two supplemented samples were obtained, SAMPLE A [50:50] and SAMPLE B [70:30] of yam flour and soybean pomace respectively. The samples were subjected to proximate analysis. SAMPLE A [50:50] contained 7.026 %, 2.07 %, 4.06 %, 23.07 %, 6.04 %, 57.71 % and 377.57 kcal of moisture, fibre, ash, protein, fat and carbohydrate respectively while SAMPLE B [70:30] contained 7.10 %, 1.21 %, 2.49 %, 17.33 %, 4.17 %, 67.69 % and 377.661 kcal of moisture, fibre, ash, protein, fat and carbohydrate respectively. Therefore enriched yam flour with pomace is of high protein and it will reduce the problems of malnutrition were yam flour is consumed as staple food.

Page(s): 22-24                                                                                                                   Date of Publication: 18 February 2019

 Gbenga Daniel Abata
Department of Nutrition and Dietetics, Federal Polytechnic Ede Osun State, Nigeria

 Emmanuel Orimisan Abata
Departments of Chemistry, Federal University of Technology, Akure, Nigeria

 Daniel Babatunde Lene
Departments of Chemistry, Federal University of Technology, Akure, Nigeria

 Margaret M. Mosimabale
Department of Nutrition and Dietetics, Federal Polytechnic Ede Osun State, Nigeria

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[11]. Awoyale, W., Maziya‐Dixon, B., Sanni, L. O. and Shittu, T. A. (2016), Effect of water yam (Dioscoreaalata) flour fortified with distiller’s spent grain on nutritional, chemical, and functional properties. Food Science Nutrition, 4: 24-33. doi:10.1002/fsn3.254

Gbenga Daniel Abata, Emmanuel Orimisan Abata, Daniel Babatunde Lene, Margaret M. Mosimabale “Nutritional Composition of Yam Flour Fortified with Soy-Pomace” International Journal of Research and Scientific Innovation (IJRSI) vol.6 issue 2, pp.22-24 February 2019 URL: https://www.rsisinternational.org/journals/ijrsi/digital-library/volume-6-issue-2/22-24.pdf

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Cloud Computing: An Overview, Benefits, Issues & Research Challenges
Mahendra Prasad Nath, Roopa Sridharan, Amit Bhargava, Thariq Mohammed – February 2019 – Page No.: 25-35

Cloud computing is a lot of IT benefits that are given to a client over a system on a rented premise and with the capacity to scale up or down their administration prerequisites. Normally Cloud Computing administrations are conveyed by an outsider supplier who possesses the framework. Cloud computing holds the possibility to dispose of the prerequisites for setting up of surprising expense figuring framework for IT-based arrangements and administrations that the business employments. It guarantees to give an adaptable IT design, available through web from light weight convenient gadgets. This would permit multi-crease increment in the limit and abilities of the current and new software. This new financial model for registering has discovered ripe ground and is pulling in huge worldwide speculation. Numerous businesses, for example, managing an account, social insurance and training are moving towards the cloud because of the productivity of administrations given by the compensation per-use design dependent on the assets, for example, preparing power utilized, exchanges completed, transmission capacity expended, information exchanged, or storage room involved and so forth. In a cloud computing condition, the whole information lives over a lot of organized assets, empowering the information to be gotten to through virtual machines. Not with standing the potential increases accomplished from the cloud computing, the associations are moderate in tolerating it because of security issues and difficulties related with it. Security is one of the serious issues which hamper the development of cloud. There are different research difficulties likewise there for embracing cloud computing, for example, very much overseen administration level understanding (SLA), protection, interoperability and unwavering quality. This exploration paper presents what cloud computing is, the different cloud models and the diagram of the cloud computing engineering. This examination paper likewise dissects the key research difficulties present in cloud computing and offers best practices to specialist co-ops just as ventures planning to use cloud administration to enhance their main concern in this extreme financial atmosphere.

Page(s): 25-35                                                                                                                   Date of Publication: 19 February 2019

 Mahendra Prasad Nath
Cognizant Technology Solutions India Pvt. Ltd., Manyata Embassy Business Parks, Bengaluru, Karnataka 560045, India

 Roopa Sridharan
Cognizant Technology Solutions India Pvt. Ltd., Manyata Embassy Business Parks, Bengaluru, Karnataka 560045, India

 Amit Bhargava
Cognizant Technology Solutions India Pvt. Ltd., Manyata Embassy Business Parks, Bengaluru, Karnataka 560045, India

 Thariq Mohammed
Cognizant Technology Solutions India Pvt. Ltd., Manyata Embassy Business Parks, Bengaluru, Karnataka 560045, India

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Mahendra Prasad Nath, Roopa Sridharan, Amit Bhargava, Thariq Mohammed “Cloud Computing: An Overview, Benefits, Issues & Research Challenges” International Journal of Research and Scientific Innovation (IJRSI) vol.6 issue 2, pp. 25-35 February 2019 URL: https://www.rsisinternational.org/journals/ijrsi/digital-library/volume-6-issue-2/25-35.pdf

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A Study on Cyber Crime: Types and Area of Improvement

Satya Priya, Riya Khurana, Preeti Singla- February 2019 Page No.: 36-37

In this era of globalization, modernization and industrialization everyone is engaged online which has caused a huge damage on individuals as well as on organizations and many others sectors of the economy. This paper contains currently increasing ratio of online crimes and their unauthentic acts. This paper also shows a wide comparison between the increased numbers of hackers through online data. This paper describes the need to stop cybercrime and also gives details of the harm it has caused to the current environment. The paper also shows studies made on cyber-oriented crimes and types of cybercrimes nowadays. In addition some of the case studies related to cyber crimes are listed below.

Page(s): 36-37                                                                                                                   Date of Publication: 19 February 2019

 Satya Priya
Student of CSE, Chandigarh University, Gharuan, Punjab, India

 Riya Khurana
Student of BBA, Chandigarh University, Gharuan, Punjab, India

 Preeti Singla
Assistant Professor of Electrical Engineering, Chandigarh University, Gharuan, Punjab, India

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[8]. Max Goodman, “Future crimes”, 24 Feb, 2015, ISBN:0552170801
[9]. Neelesh Jain, Vibhash Shrivastava, “Cybercrime Changing everything- An Empirical Study”.ISSN:2250-1797

Satya Priya, Riya Khurana, Preeti Singla “A Study on Cyber Crime: Types and Area of Improvement ” International Journal of Research and Scientific Innovation (IJRSI) vol.6 issue 2, pp.40-42 February 2019  URL: https://www.rsisinternational.org/journals/ijrsi/digital-library/volume-6-issue-2/40-42.pdf

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